A SEMISYNTHETIC METHOD OF PREPARING NEOSAXITOXIN

A semisynthetic method of preparing neosaxitoxin in quantities of a purity sufficient to allow the compound to be used as an active pharmaceutical ingredient (API) is described. The scalable method includes the reductive desulfonation of an unresolved mixture of gonyautoxin 1 (GTX1) and gonyautoxin...

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Bibliographic Details
Main Authors VAN GINKEL, ROELOF, WAUGH, CRAIG ALAN, SELWOOD, ANDREW IAN
Format Patent
LanguageEnglish
French
Published 26.03.2020
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HETEROCYCLIC COMPOUNDS
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:A semisynthetic method of preparing neosaxitoxin in quantities of a purity sufficient to allow the compound to be used as an active pharmaceutical ingredient (API) is described. The scalable method includes the reductive desulfonation of an unresolved mixture of gonyautoxin 1 (GTX1) and gonyautoxin 4 (GTX4) isolated from an extract of a culture of Alexandrium pacificum grown to high cell densities in aerated vertical columns of amended sea water. L'invention concerne un procédé semi-synthétique de préparation de néosaxitoxine en quantités d'une pureté suffisante pour permettre au composé d'être utilisé en tant qu'ingrédient pharmaceutique actif (API). Le procédé évolutif comprend la désulfonation réductrice d'un mélange non résolu de gonyautoxine 1 (GTX1) et de gonyautoxine 4 (GTX4) isolé à partir d'un extrait d'une culture d'Alexandrium pacificum cultivé à des densités cellulaires élevées dans des colonnes verticales aérées d'eau de mer modifiée.
Bibliography:Application Number: CA20183113727