PRMT5 INHIBITORS

The present invention provides a compound of Formula (I) and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are PRMT5 inhibitors. Also provided are methods of making compounds of Formula I, pharmaceutical compositions comprising compounds of Formula I, and methods of usin...

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Main Authors PAPARIN, JEAN-LAURENT, RAHALI, HOUCINE, SILIPHAIVANH, PHIENG, QUIROZ, RYAN, FIER, PATRICK S, HENDERSON, TIMOTHY J, SCHNEIDER, SEBASTIAN, SANYAL, SULAGNA, GIBEAU, CRAIG, SILVERMAN, STEVEN M, KAWAMURA, SHUHEI, MACHACEK, MICHELLE, SLOMAN, DAVID L, WAN, MURRAY, WITTER, DAVID, HUANG, CHUNHUI, CANDITO, DAVID A, YE, YINGCHUN, REUTERSHAN, MICHAEL H, HUGHES, JONATHAN M. E, YEUNG, CHARLES S
Format Patent
LanguageEnglish
French
Published 13.02.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention provides a compound of Formula (I) and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are PRMT5 inhibitors. Also provided are methods of making compounds of Formula I, pharmaceutical compositions comprising compounds of Formula I, and methods of using these compounds to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations. La présente invention concerne un composé de formule (I) et ses sels, esters et promédicaments pharmaceutiquement acceptables, qui sont des inhibiteurs de PRMT5. L'invention concerne également des procédés de production de composés de formule I, des compositions pharmaceutiques comprenant des composés de formule I, et des procédés d'utilisation de ces composés pour traiter le cancer, la drépanocytose et les mutations de persistance héréditaire de l'hémoglobine foetale (PHHF).
Bibliography:Application Number: CA20193108388