HALOALLYLAMINE SULFONE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF

• Main Authors: DEODHAR, MANDAR, FOOT, JONATHAN STUART, TURNER, CRAIG IVAN, GRECO, ANGELIQUE ELSA, ZHOU, WENBIN, JAROLIMEK, WOLFGANG, FINDLAY, ALISON DOROTHY, BUSON, ALBERTO
• Format: Patent
• Language: English; French
• Published: 06.02.2020
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as various uses thereof. La présente invention concerne de nouveaux composés capables d'inhiber certaines enzymes amine oxydases. Les composés selon l'invention sont utiles pour le traitement de différentes indications, par exemple, la fibrose, le cancer et/ou l'angiogenèse chez des sujets humains, ainsi que chez les animaux domestiques et le bétail. La présente invention concerne également des compositions pharmaceutiques contenant ces composés, ainsi que diverses utilisations associées.