4-(3-AMINO-6-FLUORO-1H-INDAZOL-5-YL)-1,2,6-TRIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DIC ARBONITRILE COMPOUNDS FOR TREATING HYPERPROLIFERATIVE DISORDERS

• Main Authors: LIENAU, PHILIP, KUHNKE, LARA PATRICIA, BOMER, ULF, BRIEM, HANS, BADER, BENJAMIN, HEINRICH, TOBIAS, HOLTON, SIMON, CHRIST, CLARA, FARIA ALVARES DE LEMOS, ADELAIDE CLARA, SCHULZE, VOLKER
• Format: Patent
• Language: English; French
• Published: 03.10.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention covers 4-(3-amino-6-fluoro-1H-indazol-5-yl)-1,2,6-trimethyl-1,4- dihydropyridine-3,5-dicarbonitrile compounds of general formula (I) : in which R1, R2 and R3 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases. La présente invention concerne des composés de 4-(3-amino-6-fluoro-1H-indazol-5-yl)-1,2,6-triméthyl-1,4-dihydropyridine-3,5-dicarbonitrile de formule générale (I) : dans laquelle R1, R2 et R3 sont tels que définis dans la description, l'invention concerne également, des procédés de préparation desdits composés, des composés intermédiaires utiles pour préparer lesdits composés, des compositions et des combinaisons pharmaceutiques comprenant lesdits composés et l'utilisation desdits composés pour fabriquer des compositions pharmaceutiques destinées au traitement et/ou à la prophylaxie de maladies.