COMPOUNDS FOR TARGETING DRUG DELIVERY AND ENHANCING SIRNA ACTIVITY

Compounds of the structure (retinoid)m-linker-(retinoid)n wherein m and n are independently 0, 1, 2 or 3; and wherein the linker comprises a polyethylene glycol (PEG), PEG- like molecule, Glu, G1y3 and/or GluNH are useful for facilitating drug delivery to a target cell. The retinoid may have a speci...

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Main Authors HOU, ZHENG, KARMALI, PRIYA, PAYNE, JOSEPH E, AKOPIAN, VIOLETTA, KNOPOV, VICTOR, AHMADIAN, MOHAMMAD, PERELMAN, LOREN A, WITTE, RICHARD P, GAUDETTE, JOHN A, SRIDHAR, C. NAGARAJAN, TANAKA, YASUNOBU, NIITSU, YOSHIRO
Format Patent
LanguageEnglish
French
Published 13.12.2012
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:Compounds of the structure (retinoid)m-linker-(retinoid)n wherein m and n are independently 0, 1, 2 or 3; and wherein the linker comprises a polyethylene glycol (PEG), PEG- like molecule, Glu, G1y3 and/or GluNH are useful for facilitating drug delivery to a target cell. The retinoid may have a specific receptor or activation/binding site on the target cell. Des composés de la structure (rétinoïde)m-lieur-(rétinoïde)n sont décrits, m et n étant indépendamment 0, 1, 2 ou 3, le lieur comprenant un polyéthylèneglycol, une molécule semblable à un polyéthylèneglycol, Glu, G1y3 et/ou GluHN utiles pour faciliter ladministration de médicament à une cellule cible. Le rétinoïde peut comprendre un récepteur spécifique ou un site dactivation ou de liaison sur la cellule cible.
Bibliography:Application Number: CA20123094645