C3-BINDING AGENTS AND METHODS OF USE THEREOF

• Main Authors: LIU, ZHONGHAO, HIGBEE, JARED MARTIN, ZHAI, WENWU, YIN, YIYUAN, TANG, JIE, WANG, YAN, DUEY, DANA YEN MEI
• Format: Patent
• Language: English; French
• Published: 10.10.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present disclosure provides binding agents, such as antibodies (including single chain variable fragments), that specifically bind complement component C3, including human C3, compositions comprising same, and methods of their use. The disclosure also provides related polynucleotides and vectors encoding the binding agents and cells comprising same. La présente invention concerne des agents de liaison, tels que des anticorps (y compris des fragments variables à chaîne unique), qui se lient de manière spécifique à la composante C3 du complément, notamment C3 humaine, des compositions les comprenant, et des procédés d'utilisation associés. L'invention concerne également des polynucléotides et des vecteurs associés codant pour les agents de liaison et des cellules les comprenant.