THERMALLY SENSITIVE PROTECTING GROUPS FOR CYSTEINE, AND MANUFACTURE AND USE THEREOF

In a preferred embodiment, there is provided a protected cysteine having structural formula 9 or 10: wherein X and Y are independently of each other oxygen, sulfur, nitrogen or phosphorus; RI and R2 are independently of each other hydrogen, hydroxyl, halo, alkyl, alkenyl, alkynyl, cycloalkyl, hetero...

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Main Authors CHIFOR, ANTHONY EMANUEL, MEISTER, DANIEL, NASRI, SARAH, TAIMOORY, SEYEDEH MARYAMDOKHT, HAYWARD, JOHN JAMES, DASHTI-POUR, MOHADESEH, TRANT, JOHN FREDERICK
Format Patent
LanguageEnglish
French
Published 27.02.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:In a preferred embodiment, there is provided a protected cysteine having structural formula 9 or 10: wherein X and Y are independently of each other oxygen, sulfur, nitrogen or phosphorus; RI and R2 are independently of each other hydrogen, hydroxyl, halo, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, formyl, haloformyl, carbonyl, carboxyl, alkoxy, alkoxycarbonyl, (alkoxycarbonyl)oxy; carbamoyl, amino, amido, imino, imido, azo, cyanato, isocyanato, cyano, nitro, sulfanyl, thiocyanato or phosphono, each of which is optionally substituted; R3 and R4 are independently of each other hydrogen or a protecting group; and n is an integer between 1 and 12, inclusive. Dans une réalisation préférée, il est décrit une cystéine protégée ayant une formule structurelle 9 ou 10 : X et Y étant, de manière indépendante lun de lautre, oxygène, soufre, azote ou phosphore; R1 et R2 étant, de manière indépendante lun de lautre, hydrogène, hydroxyle, halo, alkyle, alcényle, alcynyle, cycloalkyle, hétérocycloalkyle, aryle, aralkyle, hétéroaryle, hétéroaralkyle, formyle, haloformyle, carbonyle, carboxyle, alkoxy, alkoxycarbonyl, (alkoxycarbonyl)oxy; carbamoyl, amino, amido, imino, imido, azo, cyanato, isocyanato, cyano, nitro, sulfanyl, thiocyanato ou phosphono, chacun étant facultativement substitué; R3 et R4 étant, de manière indépendante lun de lautre, hydrogène, ou un groupe protecteur; et n étant un nombre entier compris entre 1 et 12.
Bibliography:Application Number: CA20203089634