CELL CULTURE METHODS

The present invention relates to methods for reducing the heterogeneity of a population of recombinant proteins produced in cell culture, said methods comprising growing host cells producing a recombinant protein in a cell culture medium wherein the cell culture medium comprises one or more cysteine...

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Bibliographic Details
Main Authors MALPHETTES, LAETITIA, CHEVALLIER, VALENTINE, COOL, VINCENT ADOLPHE CAROL, KOCHANOWSKI, NADINE
Format Patent
LanguageEnglish
French
Published 06.06.2019
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Summary:The present invention relates to methods for reducing the heterogeneity of a population of recombinant proteins produced in cell culture, said methods comprising growing host cells producing a recombinant protein in a cell culture medium wherein the cell culture medium comprises one or more cysteine/cystine analogs. La présente invention concerne des procédés pour réduire l'hétérogénéité d'une population de protéines recombinantes produites dans une culture cellulaire, lesdits procédés comprenant la culture de cellules hôtes produisant une protéine recombinante dans un milieu de culture cellulaire, le milieu de culture cellulaire comprenant un ou plusieurs analogues de cystéine/cystine.
Bibliography:Application Number: CA20183083680