ANTIBODIES AND ANTIBODY-DRUG CONJUGATES SPECIFIC FOR CD123 AND USES THEREOF

• Main Authors: HAN, YOONI, KATRAGADDA, MADAN, TUMEY, LAWRENCE NATHAN, CHARATI, MANOJ BABURAO, PICHE-NICHOLAS, NICOLE MELISSA
• Format: Patent
• Language: English; French
• Published: 02.05.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention provides antibodies that specifically bind to CD123. The invention further relates to immunoconjugates (e.g., antibody-drug conjugates, or ADCs) comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and ADCs for the treatment of a condition associated with cells expressing CD123 (e.g., cancer or autoimmune disease). La présente invention concerne des anticorps qui se lient de manière spécifique à CD123. L'invention concerne également des immuno-conjugués (par exemple, des conjugués anticorps-médicaments ou ADC) comprenant de tels anticorps, des acides nucléiques codant pour un anticorps et des procédés d'obtention de tels anticorps. L'invention concerne en outre des procédés thérapeutiques pour l'utilisation de ces anticorps et ADC dans le traitement d'une affection associée à des cellules exprimant CD123 (par exemple, un cancer ou une maladie auto-immune).