ORGAN PERFUSION APPARATUS WITH DOWNSTREAM FLOW CONTROL

• Main Authors: KRAVITZ, DAVID, LOUIS, JEFFREY S, DEMUYLDER, PETER, COPITHORNE, MATTHEW, OTTS, BRIAN L, STEINMAN, CHRISTOPHER P
• Format: Patent
• Language: English; French
• Published: 02.05.2023
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CONTROL OR REGULATING SYSTEMS IN GENERAL; CONTROLLING; FISHING; FORESTRY; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; HUMAN NECESSITIES; HUNTING; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS ORELEMENTS; PEST REPELLANTS OR ATTRACTANTS; PHYSICS; PLANT GROWTH REGULATORS; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; REGULATING; TRAPPING

An organ perfusion apparatus may include at least two tubes connected to an organ or tissue. A method of perfusing an organ or tissue may include connecting a first end of each of the at least two tubes to an organ or tissue, applying a fluid motive force to a perfusion fluid in the two tubes to force the fluid through the two tubes into the organ or tissue, and perfusing the organ or tissue through the at least two tubes such that the fluid motive force, provided by, e.g., a pump, and backpressure generated by the organ or tissue, establishes a flow balance between the at least two tubes. The flow balance may be altered without altering the fluid motive force that is applied. Un appareil de perfusion dun organe peut comprendre des tubulures reliées à un organe ou tissu. Un appareil de perfusion d'un organe ou tissu peut comprendre le fait de relier une première extrémité de chacune des tubulures à un organe ou tissu, le fait dappliquer une force motrice sur le fluide de perfusion dans les deux tubulures pour que le fluide pénètre dans l'organe ou le tissu et le fait de perfuser l'organe ou le tissu au moyen desdites tubulures de façon à ce que la force motrice, obtenue, par exemple, par la pompe et la contrepression générée par l'organe ou le tissu, établisse un débit équilibré entre lesdites tubulures. L'équilibre du débit peut être modifié sans faire varier la force motrice exercée.