ANTI-CD8 ANTIBODIES AND USES THEREOF

Provided are anti-CD8 antibodies that bind human CD8 and do not stimulate or inhibit the activation of CD8+ T cells. Also provided are nucleic acids encoding such anti-CD8 antibodies, vectors comprising such nucleic acids, host cells comprising same, and methods of making such anti-CD8 antibodies. A...

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Main Authors CHEN, YVONNE M, ALBERT, MATTHEW LAWRENCE, CHIANG, EUGENE YUUAN, GROGAN, JANE LOUISE, WILLIAMS, SIMON-PETER
Format Patent
LanguageEnglish
French
Published 14.02.2019
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:Provided are anti-CD8 antibodies that bind human CD8 and do not stimulate or inhibit the activation of CD8+ T cells. Also provided are nucleic acids encoding such anti-CD8 antibodies, vectors comprising such nucleic acids, host cells comprising same, and methods of making such anti-CD8 antibodies. Also provided are anti-CD8 antibodies conjugated to a detectable label. Provided are methods of using such anti-CD8 antibodies to detect CD8+ T cells in a subject, monitor disease progress in a subject having cancer, and monitor treatment progress in a subject having cancer. L'invention concerne des anticorps anti-CD8 qui se lient à CD8 humain et ne stimulent ni n'inhibent l'activation de lymphocytes T CD8+. L'invention concerne également des acides nucléiques codant de tels anticorps anti-CD8, des vecteurs comprenant de tels acides nucléiques, des cellules hôtes les comprenant, et des procédés de production de tels anticorps anti-CD8. L'invention concerne également des anticorps anti-CD8 conjugués à une étiquette détectable. L'invention concerne des procédés d'utilisation de tels anticorps anti-CD8 pour détecter des lymphocytes T CD8+ chez un sujet, surveiller l'évolution d'une maladie chez un sujet atteint d'un cancer, et surveiller les progrès du traitement chez un sujet atteint d'un cancer.
Bibliography:Application Number: CA20183070297