NEGATIVE-POSITIVE ENRICHMENT FOR NUCLEIC ACID DETECTION

The invention provides methods of detecting a feature of interest in a nucleic acid sample by negatively and positively enriching the sample for segments that contain the feature of interest. Negative enrichment may include digestion of nucleic acids that do not contain the segments, and positive en...

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Bibliographic Details
Main Author SHUBER, ANTHONY P
Format Patent
LanguageEnglish
French
Published 20.12.2018
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
ENZYMOLOGY
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
PROCESSES OF PREPARING SUCH COMPOSITIONS
SPIRITS
VINEGAR
WINE
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Summary:The invention provides methods of detecting a feature of interest in a nucleic acid sample by negatively and positively enriching the sample for segments that contain the feature of interest. Negative enrichment may include digestion of nucleic acids that do not contain the segments, and positive enrichment may include purification of the segments. The methods are useful for diagnostic of genetic elements, e.g., elements indicative of cancer. L'invention concerne des procédés de détection d'une caractéristique d'intérêt dans un échantillon d'acide nucléique par enrichissement négatif et positif de l'échantillon visant à identifier les segments qui contiennent la caractéristique d'intérêt. L'enrichissement négatif peut comprendre la digestion des acides nucléiques qui ne contiennent pas les segments, et l'enrichissement positif peut comprendre la purification des segments. Ces procédés sont utiles pour le diagnostic d'éléments génétiques, p. ex., les éléments indicateurs de cancer.
Bibliography:Application Number: CA20183069934