ANALYTICAL AND THERAPEUTIC METHODS AND COMPOSITIONS, AND USES THEREOF

The invention generally relates to compositions and methods for treating, detecting and assisting in the diagnosis of Streptococcus pyogenes infection, of rheumatic fever or of poststreptococcal glomerulonephritis (PSGN), and compositions and methods for assessing the propensity for developing rheum...

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Bibliographic Details
Main Authors MORELAND, NICOLE J, YOUNG, PAUL GARY, PROFT, THOMAS
Format Patent
LanguageEnglish
French
Published 01.11.2018
Subjects
CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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Summary:The invention generally relates to compositions and methods for treating, detecting and assisting in the diagnosis of Streptococcus pyogenes infection, of rheumatic fever or of poststreptococcal glomerulonephritis (PSGN), and compositions and methods for assessing the propensity for developing rheumatic fever or PSGN in subjects in need thereof. Recombinant polypeptides, including recombinant Streptococcus pyogenes SpnA polypeptides, and compositions comprising such polypeptides, for use in such methods are also provided. De manière générale, l'invention concerne des compositions et des méthodes de traitement, de dépistage et d'aide au diagnostic d'une infection à Streptococcus pyogenes, de la fièvre rhumatismale ou de la glomérulonéphrite post-streptococcique (PSGN), et des compositions et des méthodes pour évaluer la propension à développer une fièvre rhumatismale ou la PSGN chez des sujets en ayant besoin. Des polypeptides recombinés, dont des polypeptides SpnA de Streptococcus pyogenes recombinés, et des compositions les contenant, pour une utilisation dans ces méthodes sont en outre décrits.
Bibliography:Application Number: CA20183061727