METHODS OF MANUFACTURING OF NIRAPARIB

Disclosed herein are methods and processes of preparing niraparib and pharmaceutically acceptable salts thereof, and intermediates and their salts useful for the synthesis of niraparib. In another aspect disclosed herein is a process to form an enantiomerically enriched (S)-niraparib. Formula (7) is...

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Bibliographic Details
Main Authors CHEN, FRANK XING, WU, GEORGE, STEWART, ALISTAIR, TOTO, ANTHONY JOSEPH
Format Patent
LanguageEnglish
French
Published 01.11.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Disclosed herein are methods and processes of preparing niraparib and pharmaceutically acceptable salts thereof, and intermediates and their salts useful for the synthesis of niraparib. In another aspect disclosed herein is a process to form an enantiomerically enriched (S)-niraparib. Formula (7) is representative: Des méthodes et des procédés de préparation de niraparib et de sels connexes acceptables sur le plan pharmaceutique, d'intermédiaires et de sels utiles pour la synthèse de niraparib sont décrits. Selon un autre aspect, un procédé est décrit pour former un (S)-niraparib enrichi de façon énantiomérique. La formule (7) est représentative :
Bibliography:Application Number: CA20183060715