DEVICES, METHODS, AND COMPOSITIONS USEFUL IN CRYO-PRESERVATION, -STORAGE, -TRANSPORT, AND APPLICATION OF THERAPEUTIC MAMMALIAN CELLS

• Main Authors: TANDESKI, TERRY, DULATOV, GALINA, ERICKSON, ISAAC, SILVERMAN, LARA
• Format: Patent
• Language: English; French
• Published: 07.09.2018
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; BEER; BIOCHEMISTRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY; ENZYMOLOGY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; SPIRITS; TRAPPING; VINEGAR; WINE

The disclosed compositions, methods, and devices are useful in freezing, storing, and administering therapeutic eukaryotic cells to a patient in need thereof. In many embodiments, the disclosed therapeutic cells are mammalian cells derived from human intervertebral disc tissue. The disclosed compositions, methods, and devices are able to maintain high viability and sterility of the therapeutic cells, and allow the cells to be administered to a patient directly from the freezing container without manipulation of the cells or transferring to a second container. La présente invention concerne des compositions, des procédés et des dispositifs utiles pour la congélation, le stockage et l'administration de cellules eucaryotes thérapeutiques pour un patient dont l'état le nécessite. Selon de nombreux modes de réalisation, les cellules thérapeutiques de l'invention sont des cellules de mammifère issues de tissu de disque intervertébral humain. Les compositions, les procédés et les dispositifs de l'invention sont aptes à maintenir une viabilité et une stérilité élevées des cellules thérapeutiques, et permettent aux cellules d'être administrées à un patient directement à partir du récipient de congélation sans manipulation des cellules ni transfert dans un second récipient.