SUBSTITUTED PYRAZOLO[1,5-A]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS

Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, D, E, X1, X2, X3 and X4 have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of disea...

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Main Authors WALLS, SHANE M, BLAKE, JAMES F, ANDREWS, STEVEN W, JIANG, YUTONG, REN, LI, KOLAKOWSKI, GABRIELLE R, MORENO, DAVID A, HAAS, JULIA
Format Patent
LanguageEnglish
French
Published 14.06.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, D, E, X1, X2, X3 and X4 have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including diseases or disorders mediated by a RET kinase. La présente invention concerne des composés de formule I : et des stéréoisomères et des sels ou des solvates pharmaceutiquement acceptables correspondants. Dans la formule I, A, B, D, E, X1, X2, X3 et X4 présentent les significations données dans la description, qui sont des inhibiteurs de la kinase RET et qui sont utiles dans le traitement et la prévention de maladies qui peuvent être traitées avec un inhibiteur de la kinase RET, y compris des maladies ou des troubles induits par une kinase RET.
Bibliography:Application Number: CA20183049136