A SIRPALPHA-41BBL FUSION PROTEIN AND METHODS OF USE THEREOF

SIRPalpha-41BBL fusion proteins are provided. Accordingly, there is provided a SIRPalpha-41BBL fusion protein comprising a single amino acid linker between the SIRPalpha and the 41BBL. Also there is provided a SIRPalpha-41BBL fusion protein in a form of at least a homo-trimer. Also provided are poly...

Full description

Saved in:
Bibliographic Details
Main Authors SHANI, NOAM, GOZLAN, YOSI, DRANITZKI ELHALEL, MICHAL, KAMINSKY, IDO, BREMER, EDWIN
Format Patent
LanguageEnglish
French
Published 12.07.2018
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:SIRPalpha-41BBL fusion proteins are provided. Accordingly, there is provided a SIRPalpha-41BBL fusion protein comprising a single amino acid linker between the SIRPalpha and the 41BBL. Also there is provided a SIRPalpha-41BBL fusion protein in a form of at least a homo-trimer. Also provided are polynucleotides and nucleic acid constructs encoding the SIRPalpha-41BBL fusion protein, host-cells expressing the SIRPalpha-41BBL fusion protein and methods of use thereof. L'invention concerne des protéines de fusion SIRP1alpha-41BBL. L'invention concerne une protéine de fusion SIRPalpha-41BBL comprenant un seul lieur d'acide aminé entre le SIRPalpha et le 41BBL. L'invention concerne également une protéine de fusion SIRPalpha-41BBL sous la forme d'au moins un homo-trimère. L'invention concerne en outre des polynucléotides et des constructions d'acides nucléiques codant pour la protéine de fusion SIRP1alpha-41BBL, des cellules hôtes exprimant la protéine de fusion SIRP1alpha-41BBL et leurs procédés d'utilisation.
Bibliography:Application Number: CA20183047708