USE OF CHYMASE INHIBITORS FOR THE TREATMENT OF ENDOMETRIOSIS, POSTOPERATIVE FIBROSIS AND DISORDERS THAT ARE CHARACTERIZED BY FIBROSIS

• Main Authors: PETERS, MICHAELE, ZOLLNER, THOMAS, KOCH, MARKUS
• Format: Patent
• Language: English; French
• Published: 28.06.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to the use of by cyclically-substituted uracil derivatives, on their own or in combination with other active substances, for the treatment and/or prophylaxis of illnesses, in particular for the treatment and/or prophylaxis of inflammatory and fibrotic diseases, for the treatment of endometriosis, of endometriosis-associated fibrosis, of adenomyosis, and of pain associated with an endometriotic disease, and of post-operative peritoneal fibrosis and adhesion formation. La présente invention concerne l'utilisation de dérivés de l'uracile à substitution bicyclique, seuls ou combinés à d'autres principes actifs, pour le traitement et/ou la prophylaxie de maladies, en particulier pour le traitement et/ou la prophylaxie de maladies inflammatoires et fibrotiques, pour le traitement de l'endométriose, de la fibrose associée à l'endométriose, de l'adénomyose et de troubles associés à l'endométriose, ainsi que de la fibrose péritonéale post-opératoire et la formation d'adhérences.