THERAPEUTICALLY ACTIVE COMPLEXES

A biologically active complex comprising a peptide of up to 50 amino acids in length which comprises an alpha-helical domain of a protein which has membrane perturbing activity or a variant thereof which lacks cysteine residues, and oleic acid or a salt thereof, provided the protein is other than al...

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Bibliographic Details
Main Authors SVANBORG, CATHARINA, HO, CHIN SHING, MOK, KENNETH HUN, NADEEM, AFTAB
Format Patent
LanguageEnglish
French
Published 28.06.2018
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A biologically active complex comprising a peptide of up to 50 amino acids in length which comprises an alpha-helical domain of a protein which has membrane perturbing activity or a variant thereof which lacks cysteine residues, and oleic acid or a salt thereof, provided the protein is other than alpha-lactalbumin. Complexes of this type are useful in therapy, in particular cancer therapy. L'invention concerne un complexe biologiquement actif comprenant un peptide ayant une longueur allant jusqu'à 50 acides aminés qui comprend un domaine en hélice alpha d'une protéine qui a une activité de perturbation de la membrane ou d'un variant de celle-ci qui est dépourvu de résidus de cystéine, et de l'acide oléique ou un sel de celui-ci, à condition que la protéine soit différente de l'alpha-lactalbumine. Les complexes de ce type sont utiles en thérapie, en particulier en thérapie anticancéreuse.
Bibliography:Application Number: CA20173047114