SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS

• Main Authors: BLAKE, JAMES F, ANDREWS, STEVEN W, JIANG, YUTONG, MCKENNEY, MEGAN L, MCNULTY, OREN T, RAMANN, GINELLE A, REN, LI, BRANDHUBER, BARBARA J, MORENO, DAVID A, HAAS, JULIA, MCFADDIN, ELIZABETH A, WALLS, SHANE M, TANG, TONY P, COLLIER, JAMES, METCALF, ANDREW T, KOLAKOWSKI, GABRIELLE R, ARONOW, SEAN, COOK, ADAM
• Format: Patent
• Language: English; French
• Published: 19.04.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided herein are compounds of the Formula I: (I) or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X1, X2, X3, X4, Ring D, E, Ra, Rb, n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders. L'invention concerne des composés de formule I : (I) ou un sel ou un solvate pharmaceutiquement acceptable de ceux-ci, dans laquelle A, B, X 1 , X 2 , X 3 , X 4 , le cycle D, E, R a , R b , n et m ont les significations données dans la description, qui sont des inhibiteurs de la kinase RET et sont utiles dans le traitement et la prévention de maladies qui peuvent être traitées avec un inhibiteur de kinase RET, y compris des maladies et des troubles associés à RET.