INHIBITORS OF GLUCOCORTICOID RECEPTOR

The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of...

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Main Authors REW, YOSUP, SUN, DAQING, DU, XIAOHUI, YAN, XUELEI, MEDINA, JULIO C, ZHU, LIUSHENG, FANTIN, VALERIA R, MCGEE, LAWRENCE R, ZHOU, HAIYING, EKSTEROWICZ, JOHN, BALBAS, MINNA DELARAE
Format Patent
LanguageEnglish
French
Published 11.04.2023
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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Summary:The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of glucocorticoid receptors. Furthermore, the subject compounds and compositions are useful for the treatment of cancer. La présente invention concerne généralement des compositions et des méthodes de traitement du cancer et de l'hypercortisolisme. L'invention concerne des composés dérivés stéroïdiens substitués et des compositions pharmaceutiques comprenant lesdits composés. Les composés et compositions selon l'invention sont utiles pour inhiber les récepteurs glucocorticoïdes. Ces composés et compositions sont en outre utiles pour le traitement du cancer.
Bibliography:Application Number: CA20173039636