ALPHA(V)BETA(6) INTEGRIN-BINDING PEPTIDES AND METHODS OF USE THEREOF

The present invention provides peptide conjugates that target an integrin such as avß6 integrin. In particular embodiments, the peptide conjugates comprise a moiety such as a PEG moiety, an imaging agent, or a therapeutic agent. The peptide conjugates of the present invention are particularly useful...

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Bibliographic Details
Main Authors SUTCLIFFE, JULIE L, TANG, YNG
Format Patent
LanguageEnglish
French
Published 21.12.2017
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention provides peptide conjugates that target an integrin such as avß6 integrin. In particular embodiments, the peptide conjugates comprise a moiety such as a PEG moiety, an imaging agent, or a therapeutic agent. The peptide conjugates of the present invention are particularly useful for imaging a tumor, organ, or tissue. Compositions and kits containing the peptide conjugates of the present invention are also provided herein. La présente invention concerne des conjugués peptidiques qui ciblent une intégrine telle quE l'intégrine ?ß6. Dans des modes de réalisation particuliers, les conjugués peptidiques comprennent une fraction telle qu'une fraction PEG, un agent d'imagerie ou un agent thérapeutique. Les conjugués peptidiques de la présente invention sont particulièrement utiles pour l'imagerie d'une tumeur, d'un organe ou d'un tissu. L'invention concerne également des compositions et des kits contenant les conjugués peptidiques de l'invention.
Bibliography:Application Number: CA20173027364