KRAS G12C INHIBITORS

The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor. La présente invention concerne des compo...

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Main Authors MEJIA, MACEDONIO J, BLAKE, JAMES F, MARX, MATTHEW ARNOLD, CHRISTENSEN, JAMES GAIL, FELL, JAY BRADFORD, HICKEN, ERIK JAMES, BURGESS, LAURENCE E, CHICARELLI, MARK JOSEPH, VIGERS, GUY P.A, SAVECHENKOV, PAVEL, FISCHER, JOHN P, ZECCA, HENRY J, HINKLIN, RONALD JAY, GAUDINO, JOHN J, LEE, MATTHEW RANDOLF
Format Patent
LanguageEnglish
French
Published 23.11.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor. La présente invention concerne des composés qui inhibent l'activité de KRas G12C. En particulier, la présente invention concerne des composés qui inhibent de manière irréversible l'activité de KRas G12C, des compositions pharmaceutiques comprenant lesdits composés et des procédés d'utilisation de ceux-ci.
Bibliography:Application Number: CA20173024523