FUSED PENTACYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY

A series of substituted fused pentacyclic benzimidazole derivatives,and analogues thereof,being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurode...

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Main Authors LEPISSIER, LUCE ELSA, LOWE, MARTIN ALEXANDER, HEER, JAG PAUL, DELIGNY, MICHAEL LOUIS ROBERT, KEYAERTS, JEAN
Format Patent
LanguageEnglish
French
Published 05.10.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A series of substituted fused pentacyclic benzimidazole derivatives,and analogues thereof,being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. L'invention concerne une série de dérivés d'imidazole pentacycliques condensés substitués qui sont de puissants modulateurs de l'activité du TNFa humain, et sont ainsi efficaces dans le traitement et/ou la prévention de diverses affections humaines, dont les troubles auto-immuns et inflammatoires ; les troubles neurologiques et neurodégénératifs ; la douleur et les troubles nociceptifs ; les troubles cardiovasculaires ; les troubles métaboliques ; les troubles oculaires ; et les troubles oncologiques.
Bibliography:Application Number: CA20173019245