MODIFIED HYALURONIC ACID, METHOD FOR MAKING SAME AND USES THEREOF

• Main Authors: KRAUS, ANDREAS, VILLAIN, FRANCK, LINKO, ALEXANDER
• Format: Patent
• Language: English; French
• Published: 28.09.2017
• Subjects: AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; DERIVATIVES THEREOF; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; GENERAL PROCESSES OF COMPOUNDING; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORGANIC MACROMOLECULAR COMPOUNDS; POLYSACCHARIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; THEIR PREPARATION OR CHEMICAL WORKING-UP; WORKING-UP

The present invention generally relates to a modified hyaluronic acid (HA) and to a method for making same, more specifically to a (poly)glycerol-modified HA derivative prepared by grafting glycidol to HA. The present invention also relates to the use of the HA derivative for preparing a dermal filler composition, a hydrogel comprising cross-linked HA and the (poly)glycerol-modified HA derivative, and a method for preparing said hydrogel. Furthermore, the present invention relates to the use of the hydrogel as a cosmetic and/or aesthetic product, in particular as a dermal filler for tissue filling, replacing and/or augmenting. La présente invention concerne d'une manière générale un acide hyaluronique modifié (HA) et un procédé pour le fabriquer, plus précisément un dérivé HA modifié au (poly)glycérol préparé par greffage de glycidol au HA. La présente invention concerne également l'utilisation du dérivé HA pour la préparation d'une composition de charge dermique, un hydrogel comprenant du HA réticulé et le dérivé HA modifié au (poly)glycérol, et un procédé de préparation dudit hydrogel. En outre, la présente invention décrit l'utilisation de l'hydrogel comme produit cosmétique et/ou esthétique, en particulier comme charge dermique pour le remplissage, le remplacement et/ou l'augmentation tissulaires.