KINASE INHIBITORS

There are provided compounds of formula I, (I) wherein T, A, Q, Z, G, R4, R5a, R5b and n have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinas...

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Bibliographic Details
Main Authors FYFE, MATTHEW COLIN THOR, THOM, STEPHEN MALCOLM
Format Patent
LanguageEnglish
French
Published 12.10.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:There are provided compounds of formula I, (I) wherein T, A, Q, Z, G, R4, R5a, R5b and n have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines. L'invention concerne des composés représentés par la formule I, (I) dans laquelle T, A, Q, Z, G, R4, R5a à R5b et n ont les significations données dans la description, ces composés ayant une activité anti-inflammatoire (p. ex., par inhibition d'un ou de plusieurs des éléments de la famille des enzymes de protéine kinase activées par le mitogène p38 ; la kinase Syk ; et des éléments de la famille Src des tyrosines kinases) et ayant un intérêt thérapeutique, y compris dans des combinaisons pharmaceutiques, en particulier dans le traitement de maladies inflammatoires, y compris des maladies inflammatoires du poumon, de l'il et des intestins.
Bibliography:Application Number: CA20173015978