HUMAN ANTIBODIES AND BINDING FRAGMENTS THEREOF TO TENASCIN

The present disclosure relates fully antibodies and binding fragments, to a Tenascin, in particular the FBG domain of a Tenascin, which are potentially less immunogenic than the parent antibody. The disclosure also relates to composition comprising the antibody or binding fragment and use of any one...

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Bibliographic Details
Main Authors CULBERT, ERIC, MIDWOOD, KIM SUZANNE, HEXTALL, PATRICK
Format Patent
LanguageEnglish
French
Published 17.08.2017
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
TESTING
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Summary:The present disclosure relates fully antibodies and binding fragments, to a Tenascin, in particular the FBG domain of a Tenascin, which are potentially less immunogenic than the parent antibody. The disclosure also relates to composition comprising the antibody or binding fragment and use of any one of the same for diagnosis, prognosis and/or treatment of disorders such as those associated with chronic inflammation. The disclosure further provides methods of making said antibodies. La présente invention concerne des anticorps entiers et leurs fragments de liaison à une ténascine, en particulier au domaine FBG d'une ténascine, qui sont potentiellement moins immunogènes que l'anticorps parent. L'invention concerne également une composition comprenant l'anticorps ou son fragment de liaison et l'utilisation de l'un ou l'autre de ceux-ci pour le diagnostic, le pronostic et/ou le traitement de troubles tels que ceux associés à l'inflammation chronique. L'invention concerne en outre des procédés de fabrication desdits anticorps.
Bibliography:Application Number: CA20173013168