POLYUNSATURATED FATTY ACID SYNTHASE NUCLEIC ACID MOLECULES AND POLYPEPTIDES, COMPOSITIONS, AND METHODS OF MAKING AND USES THEREOF

• Main Authors: RICHTER, LESLIE, SIMPSON, DAVID, APT, KIRK E, ZIRKLE, ROSS
• Format: Patent
• Language: English; French
• Published: 07.09.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present invention is directed to isolated nucleic acid molecules and polypeptides of thraustochytrid polyunsaturated fatty acid (PUFA) synthases involved in the production of PUFAs, including PUFAs enriched in docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), or a combination thereof. The present invention is directed to vectors and host cells comprising the nucleic acid molecules, polypeptides encoded by the nucleic acid molecules, compositions comprising the nucleic acid molecules or polypeptides, and methods of making and uses thereof La présente invention concerne des molécules isolées dacide nucléique et des synthases de polypeptides dacide gras polyinsaturé de thraustochytrides utilisés dans la production de polypeptides dacide gras polyinsaturé, y compris les polypeptides dacide gras polyinsaturé enrichis dacide docosahexaénoïque, dacide eicosapentanoïque ou dune combinaison des deux. La présente invention concerne les véhicules et les cellules hôtes qui constituent les molécules dacide nucléique, les polypeptides codés par les molécules dacide nucléique, les compositions composées de molécules dacide nucléique ou de polypeptides et des méthodes de production et dutilisation de ceux-ci.