IMINOTETRAHYDROPYRIMIDINONE DERIVATIVES AS PLASMEPSIN V INHIBITORS

A series of 2-imino-6-methyltetrahydropyrimidin-4(lH)-one derivatives, substituted in the 6-position by a phenyl moiety which in turn is meta-substituted by an optionally substituted unsaturated fused bicyclic ring system containing at least one nitrogen atom, being selective inhibitors of plasmepsi...

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Main Authors DE HARO GARCIA, TERESA, LOWE, MARTIN ALEXANDER, CHARLTON, REBECCA LOUISE, TAYLOR, RICHARD DAVID, ZHU, ZHAONING, MACCOSS, MALCOLM, MORGAN, TREVOR
Format Patent
LanguageEnglish
French
Published 01.06.2017
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Summary:A series of 2-imino-6-methyltetrahydropyrimidin-4(lH)-one derivatives, substituted in the 6-position by a phenyl moiety which in turn is meta-substituted by an optionally substituted unsaturated fused bicyclic ring system containing at least one nitrogen atom, being selective inhibitors of plasmepsin V activity, are beneficial as pharmaceutical agents, especially in the treatment of malaria. L'invention concerne une série de dérivés de 2-imino-6-méthyltétrahydropyrimidin-4(lH)-one, substitués en position 6 par une fraction phényle qui, à son tour, est méta-substituée par un système bicyclique fusionné insaturé éventuellement substitué contenant au moins un atome d'azote, lesdits dérivés étant des inhibiteurs sélectifs de l'activité de la plasmepsine V, et étant bénéfiques comme agents pharmaceutiques, en particulier pour le traitement du paludisme.
Bibliography:Application Number: CA20163005809