4'-SUBSTITUTED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS AND PREPARATIONS THEREOF

• Main Authors: CLEATOR, EDWARD, DIEGUEZ VAZQUEZ, ALEJANDRO, SONG, ZHIGUO JAKE, KONG, JONGROCK, KEEN, STEPHEN PHILIP, MOORE, JEFFREY C, GIBSON, ANDREW WILLIAM, LIEBERMAN, DAVID R, WILLIAMS, MICHAEL J, MCLAUGHLIN, MARK, PENG, FENG, GIRIJAVALLABHAN, VINAY M, MILCZEK, ERIKA M, BELYK, KEVIN M
• Format: Patent
• Language: English; French
• Published: 18.05.2021
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; DERIVATIVES THEREOF; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

The present invention is directed to 4'-substituted nucleoside derivatives of Formula (I) and their use in the inhibition of HIV reverse transcriptase, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS and/or ARC. The present invention also provides processes for the preparation of 4'-substituted nucleoside derivatives of Formula (I) and derivatives thereof. La présente invention concerne des dérivés nucléosidiques substitués en position 4' de formule I et leur utilisation dans l'inhibition de la transcriptase inverse du VIH, la prophylaxie d'une infection par le VIH, le traitement d'une infection par le VIH, et la prophylaxie, le traitement et le retardement de l'apparition ou de la progression du SIDA et/ou du complexe associé au SIDA. La présente invention concerne également des procédés pour la préparation de dérivés nucléosidiques substitués en position 4' de formule I et des dérivés de ceux-ci.