CELL-BOUND COMPLEMENT ACTIVATION PRODUCT ASSAYS AS COMPANION DIAGNOSTICS FOR ANTIBODY-BASED DRUGS

Methods, systems, and kits useful for determining whether a subject is likely to benefit from therapy with an antibody are provided. In particular aspects, cell-bound complement activation products (CB-CAPs) associated with B lymphocytes may serve as diagnostic biomarkers. L'invention concerne...

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Bibliographic Details
Main Authors LIU, CHAUING, AHEARN, JOSEPH M, MANZI, SUSAN M
Format Patent
LanguageEnglish
French
Published 09.02.2017
Subjects
CALCULATING
COMPUTING
COUNTING
ELECTRIC DIGITAL DATA PROCESSING
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Summary:Methods, systems, and kits useful for determining whether a subject is likely to benefit from therapy with an antibody are provided. In particular aspects, cell-bound complement activation products (CB-CAPs) associated with B lymphocytes may serve as diagnostic biomarkers. L'invention concerne des procédés, des systèmes et des kits utiles pour déterminer si un sujet est susceptible de bénéficier d'une thérapie avec un anticorps. Dans des aspects particuliers, des produits d'activation du complément liés à une cellule (CB-CAP) associés à des lymphocytes B peuvent servir de biomarqueurs diagnostiques.
Bibliography:Application Number: CA20162990722