MODULATION OF MEMBERS OF THE TNF SUPERFAMILY

The invention is in the field of TNF signalling. Compounds have been identified which are capable of modulating signalling of TNF trimers through receptors. Methods of identifying such compounds are therefore provided. The compounds themselves have utility in therapy. L'invention se rapporte au...

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Bibliographic Details
Main Authors MCMILLAN, DAVID JAMES, O'CONNELL, JAMES PHILIP, RAPECKI, STEPHEN EDWARD, WARRELLOW, GRAHAM JOHN, PORTER, JOHN ROBERT, NORMAN, TIMOTHY JOHN, ALEXANDER, RIKKI PETER, BROOKINGS, DANIEL CHRISTOPHER, KROEPLIEN, BORIS, LAWSON, ALASTAIR
Format Patent
LanguageEnglish
French
Published 22.08.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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Summary:The invention is in the field of TNF signalling. Compounds have been identified which are capable of modulating signalling of TNF trimers through receptors. Methods of identifying such compounds are therefore provided. The compounds themselves have utility in therapy. L'invention se rapporte au domaine de la signalisation du TNF. Des composés aptes à moduler la signalisation de trimères de TNF par l'intermédiaire de récepteurs ont été identifiés. L'invention concerne donc des procédés pour identifier ces composés. Les composés eux-mêmes présentent une utilité thérapeutique.
Bibliography:Application Number: CA20152987823