NOTCH PATHWAY SIGNALING INHIBITOR COMPOUNDS

The present invention provides the following compounds, or pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing said compounds useful as a Notch pathway signaling inhibitor for the treatment of named cancers, sensorineural hearing loss caused by auditory hair cell lo...

Full description

Saved in:
Bibliographic Details
Main Authors HIPSKIND, PHILIP ARTHUR, PATEL, BHARVIN KUMAR, WROBLESKI, AARON D, ZHAO, GAIYING, CLAY, JULIA MARIE, EDGE, ALBERT, GILL, JOHN C, VAN ES, HELMUTH HENDRIKUS GERARDUS
Format Patent
LanguageEnglish
French
Published 26.11.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:The present invention provides the following compounds, or pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing said compounds useful as a Notch pathway signaling inhibitor for the treatment of named cancers, sensorineural hearing loss caused by auditory hair cell loss, and inducing auditory hair cell generation. La présente invention concerne les composés suivants, ou des sels pharmaceutiquement acceptables de ceux-ci, et des compositions pharmaceutiques contenant lesdits composés utilisables en tant qu'inhibiteurs de la voie de signalisation de Notch pour le traitement de cancers désignés, de la surdité neurosensorielle provoquée par la perte de cellules ciliées du système auditif, et pour induire la génération de cellules ciliées du système auditif.
Bibliography:Application Number: CA20162987431