TETRASUBSTITUTED ALKENE COMPOUNDS AND THEIR USE

Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compounds or pharmaceutically acceptable salts thereof. The breast canc...

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Main Authors SMITH, PETER GERARD, BOCK, MARK, KORPAL, MANAV, HAO, MING-HONG, ZHU, PING, PUYANG, XIAOLING, NYAVANANDI, VIJAY KUMAR, WANG, JOHN, ZHENG, GUO ZHU, SAMAJDAR, SUSANTA
Format Patent
LanguageEnglish
French
Published 19.09.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compounds or pharmaceutically acceptable salts thereof. The breast cancer may be an ER-positive breast cancer and/or the subject in need of treatment may express a mutant ER-a protein. L'invention concerne des composés, ou des sels pharmaceutiquement acceptables de ceux-ci, et des procédés d'utilisation de ces composés pour traiter le cancer du sein en administrant à un sujet en ayant besoin une quantité thérapeutiquement efficace de ces composés ou des sels pharmaceutiquement acceptables de ceux-ci. Le cancer du sein peut être un cancer du sein ER-positif et/ou le sujet ayant besoin du traitement peut exprimer une protéine ER-a mutée.
Bibliography:Application Number: CA20162987321