HETEROCYCLIC AMIDES AS KINASE INHIBITORS

Disclosed are compounds having the formula (I): wherein R1, R2 and R3 are as defined herein, and methods of making and using the same. The present compounds may be used, for example, as inhibitors of RIP1 kinase, and may be useful for the treatment of diseases and disorders, including diseases and d...

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Main Authors JEONG, JAE U, HARRIS, PHILIP ANTHONY, WHITE, GEMMA VICTORIA, FAUCHER, NICOLAS ERIC, ANDERSON, NIALL ANDREW, DONCHE, FREDERIC G, KING, BRYAN W, EIDAM, PATRICK M, WISNOSKI, DAVID DUFF, SEHON, CLARK A, GEORGE, NICOLAS S, BANDYOPADHYAY, DEEPAK, DAUGAN, ALAIN CLAUDE-MARIE
Format Patent
LanguageEnglish
French
Published 02.01.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Disclosed are compounds having the formula (I): wherein R1, R2 and R3 are as defined herein, and methods of making and using the same. The present compounds may be used, for example, as inhibitors of RIP1 kinase, and may be useful for the treatment of diseases and disorders, including diseases and disorders mediated by RIP1 kinase. Des composés de formule (I) sont décrits : R1, R2 et R3 sont tels que définis dans la présente, et des procédés de création et d'utilisation sont aussi décrits. Lesdits composés peuvent être utilisés, par exemple, comme inhibiteurs de kinase RIP1, et ils peuvent servir au traitement de maladies et troubles, y compris des maladies et troubles provoqués par la kinase RIP1.
Bibliography:Application Number: CA20162986102