INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE FOR THE TREATMENT OF CANCER

• Main Authors: THANGAVEL, SOODAMANI, CHERUKU, SRINIVAS, GUO, WEIWEI, SISTLA, RAMESH KUMAR, ROY, SAUMYA, BALOG, JAMES AARON, PULICHARLA, NAGALAKSHMI, CHERNEY, EMILY CHARLOTTE, HUANG, AUDRIS, WILLIAMS, DAVID K, KANYABOINA, YADAGIRI, NARA, SUSHEEL JETHANAND, SHAN, WEIFANG, MARKWALDER, JAY A, THANGATHIRUPATHY, SRINIVASAN, MURUGESAN, NATESAN, SEITZ, STEVEN P
• Format: Patent
• Language: English; French
• Published: 06.10.2016
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention. L'invention concerne des composés qui modulent ou inhibent l'activité enzymatique de l'indoléamine 2,3-dioxygénase (IDO), des compositions pharmaceutiques contenant lesdits composés et des méthodes permettant de traiter les affections prolifératives, par exemple le cancer, les infections virales et/ou les affections inflammatoires à l'aide des composés selon l'invention.