METHODS OF STRATIFYING PATIENTS FOR TREATMENT WITH RETINOIC ACID RECEPTOR-.ALPHA. AGONISTS

• Main Authors: CHEN, MEI WEI, COLLINS, CINDY, EATON, MATTHEW LUCAS, GUENTHER, MATTHEW G, KE, NAN, MCKEOWN, MICHAEL R, LOPEZ, JEREMY, ORLANDO, DAVID A
• Format: Patent
• Language: English; French
• Published: 25.06.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention provides methods that define cellular populations that are sensitive to RARA agonists and identify patient subgroups that will benefit from treatment with RARA agonists. The invention also provides packaged pharmaceutical compositions that comprise a RARA agonist and instructions for determining if such agonist is suitable for use in treatment. La présente invention concerne des procédés qui définissent des populations cellulaires sensibles aux agonistes RARA et identifient des sous-groupes de patients qui bénéficieront d'un traitement avec des agonistes RARA. L'invention concerne également des compositions pharmaceutiques conditionnées qui comprennent un agoniste RARA et des instructions pour déterminer si cet agoniste est approprié pour être utilisé dans un traitement.