ASYMMETRIC CATALYTIC DECARBOXYLATIVE ALKYL ALKYLATION USING LOW CATALYST CONCENTRATIONS AND A ROBUST PRECATALYST
This invention provides efficient and scalable enantioselective methods that yield 2-alkyl-2-allylcycloalkyanone compounds with quaternary stereogenic centers. Methods include the method for the preparation of a compound of formula (I), comprising treating a compound of formula (II) or (III), with a...
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Main Authors | , , , , , , |
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Format | Patent |
Language | English French |
Published |
05.09.2023
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Subjects | |
Online Access | Get full text |
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Summary: | This invention provides efficient and scalable enantioselective methods that yield 2-alkyl-2-allylcycloalkyanone compounds with quaternary stereogenic centers. Methods include the method for the preparation of a compound of formula (I), comprising treating a compound of formula (II) or (III), with a palladium (II) catalyst under alkylation conditions.
La présente invention concerne des procédés énantiosélectifs efficaces et évolutifs qui permettent d'obtenir des composés 2-alkyle-2-allylcycloalkylanone avec des centres stéréogènes quaternaires. Les procédés comprennent le procédé pour la préparation d'un composé de formule (I) : comprenant le traitement d'un composé de formule (II) ou (III): avec un catalyseur au palladium (II) dans des conditions d'alkylation. |
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Bibliography: | Application Number: CA20162981041 |