ASYMMETRIC CATALYTIC DECARBOXYLATIVE ALKYL ALKYLATION USING LOW CATALYST CONCENTRATIONS AND A ROBUST PRECATALYST

This invention provides efficient and scalable enantioselective methods that yield 2-alkyl-2-allylcycloalkyanone compounds with quaternary stereogenic centers. Methods include the method for the preparation of a compound of formula (I), comprising treating a compound of formula (II) or (III), with a...

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Bibliographic Details
Main Authors DUQUETTE, DOUGLAS, STOLTZ, BRIAN M, NUMAJIRI, YOSHITAKA, KIM, KELLY E, CRAIG, ROBERT A, LINIGER, MARC, MARZIALE, ALEXANDER N
Format Patent
LanguageEnglish
French
Published 05.09.2023
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:This invention provides efficient and scalable enantioselective methods that yield 2-alkyl-2-allylcycloalkyanone compounds with quaternary stereogenic centers. Methods include the method for the preparation of a compound of formula (I), comprising treating a compound of formula (II) or (III), with a palladium (II) catalyst under alkylation conditions. La présente invention concerne des procédés énantiosélectifs efficaces et évolutifs qui permettent d'obtenir des composés 2-alkyle-2-allylcycloalkylanone avec des centres stéréogènes quaternaires. Les procédés comprennent le procédé pour la préparation d'un composé de formule (I) : comprenant le traitement d'un composé de formule (II) ou (III): avec un catalyseur au palladium (II) dans des conditions d'alkylation.
Bibliography:Application Number: CA20162981041