GRP94 DERIVED POLYPEPTIDES FOR INHIBITING PCSK9 AND METHODS OF USE

• Main Authors: MAYER, GAETAN, POIRIER, STEVE
• Format: Patent
• Language: English; French
• Published: 02.01.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

The present invention relates to PCSK9 inhibitors and methods of use thereof. Specifically, the invention relates to PCSK9 cell-based assay, PCSK9 inhibiting polypeptides and derivatives thereof. The invention includes pharmaceutical compositions comprising a PCSK9 inhibitor polypeptide together with a pharmaceutically acceptable carrier and method for treating cardiovascular disorders, inflammatory diseases or inflammatory response to infection. La présente invention concerne des inhibiteurs de PCSK9 et leurs procédés d'utilisation. Spécifiquement, l'invention concerne un dosage à base de cellules de PCSK9, des polypeptides inhibiteurs de PCSK9 et des dérivés de ceux-ci. L'invention comprend des compositions pharmaceutiques comprenant un polypeptide inhibiteur de PCSK9 conjointement à un support pharmaceutiquement acceptable et un procédé pour le traitement de troubles cardio-vasculaires, de maladies inflammatoires ou de réponse inflammatoire à une infection.