NUCLEOTIDES AND NUCLEOSIDES AND METHODS FOR THEIR USE IN DNA SEQUENCING

• Main Authors: HERSH, MEGAN N, STUPI, BRIAN P, LITOSH, VLADISLAV A, WU, WEIDONG, METZKER, MICHAEL L
• Format: Patent
• Language: English; French
• Published: 07.07.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; DERIVATIVES THEREOF; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; SUGARS; VINEGAR; WINE

The present invention relates generally to labeled and unlabled cleavable terminating groups and methods for DNA sequencing and other types of DNA analysis. More particularly, the invention relates in part to nuclotides and nucleosides with chemically cleavable, photocleavable, enzymatically cleavable, or non-photocleavable groups and methods for their use in DNA sequencing and its application in biomedical research. La présente invention concerne, de manière générale, des groupes de terminaison clivables, marqués et non marqués, et des procédés pour le séquençage de lADN et dautres types danalyses de lADN. Plus particulièrement, linvention concerne en partie des nucléotides et des nucléosides ayant des groupes chimiquement clivables, photoclivables, clivables par voie enzymatique, ou non photoclivables et des procédés pour leur utilisation dans le séquençage de lADN et leur application en recherche biomédicale.