FUNGAL GENOME MODIFICATION SYSTEMS AND METHODS OF USE

Compositions and methods are provided for genome modification at a target site in the genome of a filamentous fungal cell. The methods and compositions are drawn to a guide polynucleotide/Cas endonuclease system for modifying or altering the target site. Aspects in which the filamentous fungal cell...

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Main Authors WARD, MICHAEL, CHAN, JIMMY, SONG, MINGMIN, BOWER, BENJAMIN S, GU, XIAOGANG, MADRID, SUSAN MAMPUSTI, SONG, DANFENG, GE, JING
Format Patent
LanguageEnglish
French
Published 24.10.2023
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Compositions and methods are provided for genome modification at a target site in the genome of a filamentous fungal cell. The methods and compositions are drawn to a guide polynucleotide/Cas endonuclease system for modifying or altering the target site. Aspects in which the filamentous fungal cell being modified has a defective non-homologous end joining pathway are also provided. La présente invention concerne des compositions et des procédés de modification du génome au niveau d'un site cible dans le génome d'une cellule de champignon filamenteux. Les procédés et les compositions sont élaborés pour un système de polynucléotide guide/endonucléase Cas de modification ou d'altération du site cible. Sont également prévus des aspects, dans lesquels la cellule de champignon filamenteux qui est modifiée présente une voie de jonction d'extrémités défectueuse non homologue.
Bibliography:Application Number: CA20152971187