TRICYCLIC IMIDAZO-PYRIMIDINONE COMPOUNDS FOR THE MEDIATION OF LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2

The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example Alzheimer's disease. La présente invention concerne...

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Bibliographic Details
Main Authors SENDER, MATTHEW ROBERT, RIVERO, RAPHAEL ANTHONY, NEIPP, CHRISTOPHER ERNST, PERO, JOSEPH E, WAN, ZEHONG, ZHANG, XIAOMIN, WANG, JIAN, MANAS, ERIC STEVEN, PATEL, VIPULKUMAR KANTIBHAI
Format Patent
LanguageEnglish
French
Published 21.02.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example Alzheimer's disease. La présente invention concerne de nouveaux composés qui inhibent l'activité de la Lp-PLA2, des procédés pour leur préparation, des compositions les contenant et leur utilisation pour le traitement de maladies associées à l'activité de la Lp-PLA2, par exemple la maladie d'Alzheimer.
Bibliography:Application Number: CA20152970537