BCL-XL INHIBITORY COMPOUNDS AND ANTIBODY DRUG CONJUGATES INCLUDING THE SAME

Small molecule Bcl-xL inhibitorsand Antibody Drug Conjugates (ADCs) comprising small molecule Bcl-xL inhibitors are disclosed herein. The Bcl-xL inhibitors and ADCs of the disclosure are useful for, among other things, inhibiting anti-apoptotic Bcl xL proteins as a therapeutic approach towards the t...

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Main Authors TAO, ZHI-FU, SULLIVAN, GERARD M, CULLEN, STEVE C, BENNETT, NATHAN B, HAIGHT, ANTHONY R, ACKLER, SCOTT L, BOGHAERT, ERWIN R, FREY, ROBIN R, WANG, XILU, SONG, XIAOHONG, WELCH, DENNIE S, SHEN, XIAOQIANG, KUNZER, AARON R, WENDT, MICHAEL D, JUDD, ANDREW S, DOHERTY, GEORGE, SOUERS, ANDREW J
Format Patent
LanguageEnglish
French
Published 16.06.2016
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:Small molecule Bcl-xL inhibitorsand Antibody Drug Conjugates (ADCs) comprising small molecule Bcl-xL inhibitors are disclosed herein. The Bcl-xL inhibitors and ADCs of the disclosure are useful for, among other things, inhibiting anti-apoptotic Bcl xL proteins as a therapeutic approach towards the treatment of diseases that involve a dysregulated apoptosis pathway. La présente invention concerne des inhibiteurs de Bcl-xL à petites molécules et des conjugués anticorps-médicament (ADC) comprenant les inhibiteurs de Bcl-xL à petites molécules. Les inhibiteurs de Bcl-xL et les ADC de l'invention sont utiles, entre autres, pour l'inhibition de protéines anti-apoptotiques Bcl-xL en tant qu'approche thérapeutique pour le traitement de maladies qui impliquent une voie de l'apoptose dérégulée.
Bibliography:Application Number: CA20152970161