1-[2-(AMINOMETHYL)BENZYL]-2-THIOXO-1,2,3,5-TETRAHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONES AS INHIBITORS OF MYELOPEROXIDASE

• Main Authors: GAN, LI-MING, JOHANNESSON, PETRA, MICHAELSSON, ERIK, TOMKINSON, NICHOLAS, STONEHOUSE, JEFFREY PAUL, LINDSTEDT-ALSTERMARK, EVA-LOTTE, JURVA, ULRIK, INGHARDT, TORD BERTIL
• Format: Patent
• Language: English; French
• Published: 28.02.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

There are disclosed certain 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H- pyrrolo[3,2-d]pyrimidin-4-one compounds of formula (I), and pharmaceutically acceptable salts thereof, together with compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme MPO and are thereby particularly useful in the treatment or prophylaxis of cardiovascular disorders such as heart failure and coronary artery disease related conditions. L'invention concerne certains composés 1-[2-(aminométhyl)benzyl]-2-thioxo-1,2,3,5-tétrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one de formule (I), et des sels pharmaceutiquement acceptables de ces derniers, ainsi que des compositions les contenant et leur utilisation en thérapie. Les composés sont des inhibiteurs de l'enzyme MPO et sont donc particulièrement utiles dans le traitement ou la prophylaxie de troubles cardio-vasculaires tels que les affections liées à une insuffisance cardiaque et une coronaropathie.