METHODS OF PREPARING INHALABLE MICRONIZED INSULIN FOR PULMONARY DELIVERY

A method of preparing an inhalable insulin suitable for pulmonary delivery includes: dissolving an insulin raw material in an acidic solution to form a dissolved insulin solution; titrating the dissolved insulin solution with a buffer solution to form a suspension comprising micronized insulin parti...

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Bibliographic Details
Main Authors LUO, MARY ZIPING, BO, AILI, DING, JEFFREY, ZHANG, JACK YONGFENG
Format Patent
LanguageEnglish
French
Published 22.12.2020
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A method of preparing an inhalable insulin suitable for pulmonary delivery includes: dissolving an insulin raw material in an acidic solution to form a dissolved insulin solution; titrating the dissolved insulin solution with a buffer solution to form a suspension comprising micronized insulin particles; and stabilizing the micronized insulin particles. L'invention concerne un procédé de préparation d'insuline inhalable, approprié pour une administration pulmonaire, qui consiste à : dissoudre une matière première d'insuline dans une solution acide pour former une solution d'insuline dissoute ; titrer la solution d'insuline dissoute avec une solution tampon pour former une suspension comprenant des particules d'insuline micronisées ; et stabiliser les particules d'insuline micronisées.
Bibliography:Application Number: CA20152954287