6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

• Main Authors: MARTIN-MARTIN, MARIA LUZ, CONDE-CEIDE, SUSANA, VAN GOOL, MICHIEL LUC MARIA
• Format: Patent
• Language: English; French
• Published: 29.11.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(511)-one derivatives as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 2 ("mG1uR2"). The invention is also directed to pharmaceutical compositions comprising such compounds, to...