6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS

• Main Authors: MARTIN-MARTIN, MARIA LUZ, CONDE-CEIDE, SUSANA, VAN GOOL, MICHIEL LUC MARIA
• Format: Patent
• Language: English; French
• Published: 29.11.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(511)-one derivatives as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 2 ("mG1uR2"). The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention or treatment of disorders in which the mG1uR2 subtype of metabotropic receptors is involved. La présente invention concerne de nouveaux dérivés de 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one utilisés comme modulateurs allostériques négatifs (NAM) du sous-type 2 des récepteurs métabotropiques du glutamate (mGluR2). Elle concerne aussi des compositions pharmaceutiques comprenant ces composés, des procédés de préparation de ces composés et compositions, et l'utilisation de ces composés et compositions pour la prévention ou le traitement de troubles dans lesquels intervient le sous-type mGluR2 des récepteurs métabotropiques.