PROCESS FOR THE PREPARATION OF SUBSTITUTED OXIRANES AND TRIAZOLES

The present invention relates to a process for the preparation of a compound of formula I I u wherein R1 is Cl-C6-alkyl or C3-C8-cycloalkyl; and R4 is F or CI; said process comprising the following step: (i) reacting an oxo compound of the formula III wherein R1 and R4 are defined as above, with a d...

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Bibliographic Details
Main Authors VIERTELHAUS, MARTIN, GEBHARDT, JOACHIM, CHIODO, TIZIANA, GOETZ, ROLAND, EHRESMANN, MANFRED
Format Patent
LanguageEnglish
French
Published 18.10.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention relates to a process for the preparation of a compound of formula I I u wherein R1 is Cl-C6-alkyl or C3-C8-cycloalkyl; and R4 is F or CI; said process comprising the following step: (i) reacting an oxo compound of the formula III wherein R1 and R4 are defined as above, with a dimethyl sulfide of formula (CH3)2S and a dimethylsulfate of formula (CH3)2504, forming a reagent IV which is a trimethylsulfonium methylsulfate of formula RCH3)35+ CH35041, in aqueous solution in the presence of potassium hydroxide (KOH), wherein the dimethyl sulfide and the dimethyl sulfate are used in a molar ratio of 1:1 to 2:1 , and wherein at most 1 0 weight-% an organic solvent in relation to the amount of the compound of formula III, are added. Cette invention concerne un procédé de préparation de composés d'oxirane de formule II à partir de composés cétoniques III faisant appel à du sulfure de diméthyle (CH3)2S et à du sulfate de diméthyle (CH3)2SO4, qui forment le réactif IV, à savoir le méthylsulfate de triméthylsulfonium [(CH3)3S+ CH3SO4 -], en solution aqueuse en présence d'hydroxyde de potassium (KOH).
Bibliography:Application Number: CA20152952896