METHOD FOR STORING AN EMULSION-ADJUVANTED VACCINE IN A LUBRICATED MEDICAL INJECTION DEVICE
The invention relates to a method for storing an emulsion-adjuvanted vaccine in a medical injection device comprising a lubricant coating, said method comprising: (a) providing a medical injection device (1) comprising a barrel (2) having an inner surface (21); (b) forming a silicone oil layer on at...
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Main Authors | , , , |
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Format | Patent |
Language | English French |
Published |
03.12.2015
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Abstract | The invention relates to a method for storing an emulsion-adjuvanted vaccine in a medical injection device comprising a lubricant coating, said method comprising: (a) providing a medical injection device (1) comprising a barrel (2) having an inner surface (21); (b) forming a silicone oil layer on at least a part of the inner surface (21) of the barrel that is intended to be in contact with the vaccine, (c) carrying out an oxidizing plasma treatment of said layer so as to crosslink at least part of the silicone oil layer and form a lubricant coating (5), (d) filling the barrel with the emulsion-adjuvanted vaccine (6). The invention also relates to a medical injection device obtained directly from this method and to the use of plasma-treated silicone oil as a lubricant coating (5) in a medical injection device (1) comprising a barrel (2), for preventing migration of silicone from said lubricant coating (5) to an emulsion-adjuvanted vaccine (6) during storage of said vaccine in said medical injection device. |
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AbstractList | The invention relates to a method for storing an emulsion-adjuvanted vaccine in a medical injection device comprising a lubricant coating, said method comprising: (a) providing a medical injection device (1) comprising a barrel (2) having an inner surface (21); (b) forming a silicone oil layer on at least a part of the inner surface (21) of the barrel that is intended to be in contact with the vaccine, (c) carrying out an oxidizing plasma treatment of said layer so as to crosslink at least part of the silicone oil layer and form a lubricant coating (5), (d) filling the barrel with the emulsion-adjuvanted vaccine (6). The invention also relates to a medical injection device obtained directly from this method and to the use of plasma-treated silicone oil as a lubricant coating (5) in a medical injection device (1) comprising a barrel (2), for preventing migration of silicone from said lubricant coating (5) to an emulsion-adjuvanted vaccine (6) during storage of said vaccine in said medical injection device. |
Author | BONHOURE, FABIEN BRALET, NICOLAS HAMEL, JEAN-BERNARD JOUFFRAY, SEBASTIEN |
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DocumentTitleAlternate | PROCEDE DE STOCKAGE DE VACCIN A ADJUVANT EN EMULSION DANS UN DISPOSITIF D'INJECTION MEDICAL LUBRIFIE |
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Snippet | The invention relates to a method for storing an emulsion-adjuvanted vaccine in a medical injection device comprising a lubricant coating, said method... |
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SubjectTerms | ADHESIVES CHEMICAL PAINT OR INK REMOVERS CHEMISTRY COATING COMPOSITIONS, e.g. PAINTS, VARNISHES ORLACQUERS CORRECTING FLUIDS DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY DYES FILLING PASTES FUELS HUMAN NECESSITIES HYGIENE INKS LUBRICANTS LUBRICATING COMPOSITIONS MEDICAL OR VETERINARY SCIENCE METALLURGY MISCELLANEOUS APPLICATIONS OF MATERIALS MISCELLANEOUS COMPOSITIONS NATURAL RESINS PAINTS PASTES OR SOLIDS FOR COLOURING OR PRINTING PEAT PETROLEUM, GAS OR COKE INDUSTRIES POLISHES TECHNICAL GASES CONTAINING CARBON MONOXIDE USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATINGINGREDIENTS IN A LUBRICATING COMPOSITION USE OF MATERIALS THEREFOR WOODSTAINS |
Title | METHOD FOR STORING AN EMULSION-ADJUVANTED VACCINE IN A LUBRICATED MEDICAL INJECTION DEVICE |
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