METHOD FOR STORING AN EMULSION-ADJUVANTED VACCINE IN A LUBRICATED MEDICAL INJECTION DEVICE

• Main Authors: JOUFFRAY, SEBASTIEN, BONHOURE, FABIEN, HAMEL, JEAN-BERNARD, BRALET, NICOLAS
• Format: Patent
• Language: English; French
• Published: 03.12.2015
• Subjects: ADHESIVES; CHEMICAL PAINT OR INK REMOVERS; CHEMISTRY; COATING COMPOSITIONS, e.g. PAINTS, VARNISHES ORLACQUERS; CORRECTING FLUIDS; DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY; DYES; FILLING PASTES; FUELS; HUMAN NECESSITIES; HYGIENE; INKS; LUBRICANTS; LUBRICATING COMPOSITIONS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MISCELLANEOUS APPLICATIONS OF MATERIALS; MISCELLANEOUS COMPOSITIONS; NATURAL RESINS; PAINTS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; PEAT; PETROLEUM, GAS OR COKE INDUSTRIES; POLISHES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATINGINGREDIENTS IN A LUBRICATING COMPOSITION; USE OF MATERIALS THEREFOR; WOODSTAINS

The invention relates to a method for storing an emulsion-adjuvanted vaccine in a medical injection device comprising a lubricant coating, said method comprising: (a) providing a medical injection device (1) comprising a barrel (2) having an inner surface (21); (b) forming a silicone oil layer on at least a part of the inner surface (21) of the barrel that is intended to be in contact with the vaccine, (c) carrying out an oxidizing plasma treatment of said layer so as to crosslink at least part of the silicone oil layer and form a lubricant coating (5), (d) filling the barrel with the emulsion-adjuvanted vaccine (6). The invention also relates to a medical injection device obtained directly from this method and to the use of plasma-treated silicone oil as a lubricant coating (5) in a medical injection device (1) comprising a barrel (2), for preventing migration of silicone from said lubricant coating (5) to an emulsion-adjuvanted vaccine (6) during storage of said vaccine in said medical injection device.